El Sereno is a Los Angeles neighborhood in the Eastside Los Angeles region of Los Angeles County, California. The Tongva village of Otsungna was situated in today's El Sereno on the banks of a stream that was later named Arroyo Rosa de Castilla, which ran east of present-day Guardia and Farnsworth avenues. A trail connected Otsungna to the village o…El Sereno is a Los Angeles neighborhood in the Eastside Los Angeles region of Los Angeles County, California. The Tongva village of Otsungna was situated in today's El Sereno on the banks of a stream that was later named Arroyo Rosa de Castilla, which ran east of present-day Guardia and Farnsworth avenues. A trail connected Otsungna to the village of Yangna on the Los Angeles River, then on to the village of Sibagna, near the eventual site of the Mission San Gabriel. The route later became Mission Road.
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