BOSTON—The mayor of New England’s biggest city on Tuesday delivered a message to the Trump administration: Hands off. Boston has been a focus of the White House’s illegal-immigration crackdown. The Justice Department this month included the blue city on a revised list of so-called sanctuary jurisdictions it says aren’t providing sufficient

Mayor Michelle Wu said Tuesday that Boston would not comply with demands from the federal government that the city cooperate with federal immigration enforcement efforts.

Wu blasted a letter from US Attorney General Pam Bondi renewing the Trump administration’s demand that Boston end policies the president views as impeding federal immigration enforcement efforts.