Prince Frederik, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died at the age of 22. He passed away on March 1 from POLG Mitochondrial disease, a rare genetic disorder.

Prince Frederik of Luxembourg died on March 1, 2025, at the age of 22 after a prolonged battle with POLG mitochondrial disease — a rare genetic disorder that causes progressive multi-organ failure. Diagnosed at 14,

Prince Frederik of Luxembourg has died at the age of 22 after a lifelong battle with POLG mitochondrial disease, a rare genetic disorder that robs the body of energy. Diagnosed at 14, he dedicated his life to raising awareness and funding research.