At least 49 cases have been confirmed. Health officials — who are scrambling to get a handle on the vaccine-preventable outbreak — suspect 200 to 300 people may be infected.

The measles outbreak first reported in Gaines County, Texas, has doubled to 48 cases since a count released earlier this week, the Texas Department of State Health Services said Friday. The first two cases were identified in late January and the numbers have been rising since.

Most of the infections have shown up in Gaines County. Texas health officials have consistently said that vaccination is the best way for people to avoid the highly contagious airborne disease.