Dr. Michael Strong of Western University's Schulich School of Medicine & Dentistry shows how abnormal protein from the ARHGEF28 gene is deposited in a motor neuron from a person with ALS.

Researchers have uncovered a mechanism that may trigger ALS’s earliest stages, identifying proteins that mislocalize, causing ...

Of the 91 patients originally diagnosed with PMA, 20 subsequently developed upper motor neuron signs, which would qualify them as having ALS with lower motor neuron onset. Furthermore, upper motor ...

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS ... The study was published on October 31, ...

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for ...

People with ALS – the most common form of motor neuron disease – experience problems with walking, speaking, swallowing and ...

An international collaboration led by Flinders University has identified a potential biomarker for amyotrophic lateral sclerosis, also known as Motor Neuron Disease, providing a way to test the ...

This finding challenges the traditional notion that muscle wasting in ALS is a secondary result of motor neuron degeneration—when these neurons don't function normally, muscle cells aren't ...

The approval makes Relyvrio (sodium phenylbutyrate and taurursodiol) the first new therapy option for ALS – also known as motor neuron disease (MND) – since Mitsubishi Tanabe Pharma's ...

Drugs that increase vitamin A in the body could help stave off deadly motor neurone disease (MND ... occur in diseases such as MND or Amyotrophic lateral sclerosis (ALS). 'Usually, these chemicals ...

Progressive muscular atrophy (PMA) is clinically characterized solely by signs of lower motor neuron dysfunction, so patients with this condition are commonly excluded from ALS clinical trials.