Using in vivo CRISPR–Cas9 screens of CD8 + T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. STUB1 forms a complex with CHIC2, and together, they ...
Tryptophan (Trp) metabolites have emerged as key regulators of host tumor immunity and cancer patient response to immunotherapy. However, the function of and mechanism underlying Trp in ...
Researchers at Mayo Clinic have uncovered a previously hidden step in how the immune system prepares to fight cancer, a ...
A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health has discovered how the ...
The technology that gave the world mRNA COVID vaccines is being tested in a variety of new ways, and emerging research ...
Meet the Jekyll and Hyde of the immune system: activated CD8⁺ T cells. On June 24 in Nature Immunology, researchers led by Dorian McGavern at the National Institutes of Health introduce a granzyme ...
As the trained killers of the immune system, cytotoxic T cells silently save our lives every day—vanquishing viruses before they can run amok, and putting nascent cancer cells out of business before ...
As high-parameter T-cell profiling becomes increasingly central to translational research and biomarker discovery, there is ...
Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...
Creative Biolabs introduces metabolic-enhanced CAR-T development solutions to overcome T-cell exhaustion challenges ...
A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.
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