Using X-ray crystallography, researchers at Harvard Medical School, led by Stephen Harrison, determined the structure, at 4 Å resolution, of the un-bound simian immunodeficiency virus envelope ...
This article is based on a poster originally authored by David Wensel, Margaret Gartland, Jagadish Beloor, Kartika Shetty, Jana Wolf, Andrew Clark, Allan Tenorio, Max Lataillade and Mark Krystal, ...
NIAID researchers have discovered a new critical component of the CD4-binding site in gp120, named CD4-BS2, which is exclusively formed in the trimeric envelope conformation. It is believed that ...
Duke Human Vaccine Institute (DHVI) investigators used a technique called time-resolved, temperature-jump (TR, T-Jump) small-angle x-ray scattering (SAXS) to capture the spectacularly brief moment ...
Self-assembling nanoparticles presenting glycan-trimmed envelope trimers as HIV-1 vaccine candidates
The HIV-1 envelope glycoprotein (Env) mediates cell entry and is the target of the host humoral immune response. Functional Env is a trimer of noncovalent gp120-gp41 heterodimers. Rational trimer ...
The ideal HIV vaccine would elicit humoral responses effective against a broad spectrum of primary HIV strains but immunogens capable of generating such antibodies in humans have been difficult to ...
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