We report that simple glycoside donors can drastically shift the equilibria of glycosyltransferase-catalyzed reactions, transforming NDP-sugar formation from an endothermic to an exothermic process.

Carbohydrate chains play physiologically relevant roles. For instance, many biologically important proteins and lipids inside our body have carbohydrate chains attached to them. These “sugar” chains, ...

Researchers have shown that dangerous cysts, which form over time in polycystic kidney disease (PKD), can be prevented by a single normal copy of a defective gene. This means the potential exists that ...