Phys.org

Iron catalyst drives asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

Scientists at the Institute of Science Tokyo (Science Tokyo) have successfully realized the highly selective asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl ...
Nature

Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines

α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α ...
C&EN

University Of Lyon Honored For Grignard Reaction

During a symposium in June, the ACS Division of the History of Chemistry (HIST) awarded the Citation for Chemical Breakthrough to the University of Lyon, in France, in honor of the institution’s role ...
EurekAlert!

Highly selective asymmetric 1,6-addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

The reaction utilizes an iron catalyst together with an N-heterocyclic carbene (NHC) ligand, which suppresses unwanted side reactions to promote highly selective nucleophile addition. In organic ...