Meiotic recombination-related gene (e.g., DMC1, HFM1, MEIOB, MAJIN, C14ORF39/SIX6OS1, STAG3, SYCE1, SYCP2-3, TERB1-2) mutations have been identified in human subfertility or infertility. Surprisingly, ...

Keeping the genetic information stored in genomic DNA intact during the cell division cycle is crucial for almost all lifeforms. Extensive DNA damage invariably causes various adverse genomic ...

Homologous chromosome pairing is a process where maternal and paternal chromosomes of the same type are aligned, resulting in a partial exchange of genetic information through meiotic recombination.

New findings suggest an explanation for the century-old mystery of how chromosome recombination is regulated during sexual reproduction. In most higher organisms, including humans, every cell carries ...

Menopausal Hormone Therapy and Ovarian and Endometrial Cancers: Long-Term Follow-Up of the Women's Health Initiative Randomized Trials Cancers with homologous recombination deficiency (HRD) can ...

In the choreography of meiosis—the process responsible for sex cell division in all eukaryotic life—the pairing of homologous chromosomes (homologs) is essential. Errors in this process can lead to an ...

Friends of Cancer Research initiated a research partnership, inviting HRD assay developers to participate in two blinded analyses. In the first, 11 assay developers reported HRD status for the Cancer ...

The above representative microscope images showcase ultra-fine bridges, a kind of abnormal link between chromosomes that causes catastrophic genetic instability. These bridges, composed of entangled ...