Researchers have discovered how newly created neurons depend on blood flow in the adult brain to travel from their site of origin to their final location. The study in mice, published today in eLife ...

Radial neuronal migration is a critical process for the formation of the cerebral cortical layers. Although transcriptional regulators are implicated in neuronal migration, the molecular mechanisms ...

Migrating newborn neurons suffer routine double-strand DNA breaks from physical stress during brain development.

Disruptions in neuronal migration or cortical lamination can lead to profound alterations in cortical circuitry, impairing synaptic connectivity and information processing—defects linked to a range of ...

Doublecortin is a neuronal microtubule-associated protein that regulates microtubule structure in neurons. Mutations in Doublecortin cause lissencephaly and subcortical band heterotopia by impairing ...

As newborn neurons make their way through the developing brain, they must squeeze through incredibly tight spaces to reach their final destinations. Researchers discovered that this physical journey ...

Using microfluidic devices mimicking the crowded spaces in the developing brain, researchers gained novel insights into distinct modes of locomotion found in neurons. In the developing brain, neurons ...

Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, and between fibers—to reach the areas where they form neural circuits in the brain cortex. In a ...

A research team led by Professor Taesung Kim of the School of Mechanical Engineering at Sungkyunkwan University (SKKU) has ...

In the developing brain, neurons must navigate through complex and often crowded tissue to reach their final destinations—this process is crucial for proper brain formation and function. Similar to ...