Symproic significantly improved bowel function and frequency of spontaneous bowel movements in patients receiving opioids compared to placebo. The study highlighted a 47.6% difference in bowel ...

Opioids can cause opioid-induced constipation by slowing down digestion and reducing fluid in the intestines. NSAIDs like ibuprofen can irritate the stomach lining and slow digestion, leading to ...

PALM SPRINGS, California — A peripherally acting oral μ-opioid receptor antagonist is superior to placebo in treating opioid-induced constipation (OIC) and doesn't reduce the analgesic effect of ...

Tsukuba, Japan—Pain relief for patients with cancer is crucial, and opioids, such as morphine, play a vital role. However, constipation, which negatively affects the patient's quality of life, is a ...

Shionogi today announced pivotal phase III study (COMPOSE I) results showing that once-daily treatment with naldemedine significantly improved opioid-induced constipation (OIC) compared to placebo in ...

The Food and Drug Administration recently approved the tablet form of Relistor to treat opioid-induced constipation. Relistor, produced by Tarrytown, N.Y.-based Progenics Pharmaceuticals, was ...