R-loops are dynamic nucleic acid structures implicated in genome regulation and instability, yet their contributions to the tumor microenvironment (TME) of clear cell renal cell carcinoma (ccRCC) ...

There are many ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops. These ...

Fig. 3: Long-range R-loop dynamics are governed by the 6 bp periodicity of the crRNA–target strand hybrid. After locking, the R-loop length became tightly constrained around 26 bp for the T6, 30 bp ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

A new study led by researchers at The University of Texas MD Anderson Cancer Center has uncovered a previously unknown ...

R-loops are unique structures in the cell, composed of RNA–DNA hybrids and a displaced single-stranded DNA, that are commonly found around transcribed genes. However, R-loops are also dynamic and ...

Recently, the research team led by Wei Li and Chao Liu from Guangzhou Medical University Affiliated Women and Children's Medical Center, in collaboration with Fei Gao’s team from the Institute of ...

This study is achieved by Professor Wei Xu’s research team from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences. The research team established mDRIP-seq, a ...

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In a new ...