We investigated whether a continuous transcript is necessary for co-transcriptional pre-mRNA processing. Cutting an intron with the fast-cleaving hepatitis δ ribozyme, but not the slower hammerhead, ...
The DNA-packaging pRNA of bacterial virus phi29, which forms dimers and then hexamers, contains two independent tightly self-folded domains. Circularly permuted pRNAs were constructed without ...
A study finds that an RNA enzyme, or ribozyme, can evolve to produce complex RNAs efficiently but at the cost of synthesis accuracy. Key to the development of RNA-based life, which is thought to have ...
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