SMU needs some help to reach the ACC championship game in two weeks, but the Mustangs controlled what they could in their final home game of the season.

Southern Methodist heads into Saturday off a Week 12 bye. The Mustangs last played on Nov. 8 when they covered a 10-point spread in a 45-13 (Over 54.5) triumph over the Boston College Eagles. SMU is one of 4 ACC squads heading into Week 13 with 1 loss in league play.

SMU is still in contention to reach another ACC title game after Kevin Jennings accounted for four touchdowns in a 38-6 win over Louisville.

SMU will be formidable. The Mustangs stayed in the title-game hunt with a decisive 38-6 win over a Louisville team without key players. Quarterback Kevin Jennings passed for 303 yards and three touchdowns and ran for a fourth TD in the victory.

The Louisville Cardinals faced the SMU Mustangs in a Week 13 college football game. Here's the UofL score and highlights from ACC game.

Louisville Cardinals QB Miller Moss is not expected to play vs. SMU as Deuce Adams and Brady Allen take over in crucial road test.

College football Week 13 odds, picks, predictions, TV channel, streaming for Louisville Cardinals vs. SMU Mustangs ACC game on Nov. 22, 2025.

Cal is 76th in FBS in red zone offense, scoring on 83.7% of trips. SMU’s red zone defense ranks 2nd at 67.5%. SMU ranks 130th in the FBS with an average time of possession of 27:14, compared to Cal’s 78th-ranked average of 29:40.