Nature

Experimental targeted radioiodide therapy following transfection of the sodium iodide symporter gene: Effect on clonogenicity in both two-and three-dimensional models

To evaluate the potential of the expression of the sodium/iodide symporter (NIS) as a means of targeting radioiodine to tumor cells, we have employed plasmid-mediated transfection of the NIS gene into ...
JSTOR Daily

His-65 in the Proton-Sucrose Symporter is an Essential Amino Acid whose Modification with Site-Directed Mutagenesis Increases Transport Activity

Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 15 (Jul. 21, 1998), pp. 9025-9030 (6 pages) The proton-sucrose symporter that mediates phloem loading is a ...
JSTOR Daily

Na⁺ coordination at the Na2 site of the Na⁺/I⁻ symporter

The sodium/iodide symporter (NIS) mediates active I⁻ transport in the thyroid—the first step in thyroid hormone biosynthesis—with a 2 Na⁺: 1 I⁻ stoichiometry. The two Na⁺ binding sites (Na1 and Na2) ...
Nature

Targeting sodium/iodide symporter gene expression for estrogen-regulated imaging and therapy in breast cancer

Breast cancer is the most common form of female cancer and comprises 18% of all malignancies in women in the Western world. 1 Although screening programs that allow earlier detection of the disease ...
News Medical

Scientists map novel structure of so-called 'neurotransmitter: sodium symporter’

A novel structure of a so-called 'neurotransmitter: sodium symporter’ has been mapped at the University of Copenhagen. The discovery adds to the researchers’ knowledge of neurotransmitters in the ...