Telomerase synthesizes DNA sequences that protect the integrity of chromosome ends. A model for how the components of this enzyme complex co-assemble offers insight into its structure and function.

Scientists have for the first time mapped telomerase, an enzyme which has a kind of rejuvenating effect on normal cell aging. The findings are a step forward in the fight against cancer. In ...

Study shows how telomerase can run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage. The natural ends of chromosomes appear alarmingly like broken DNA, much as ...

Telomerase may be a nearly universal anticancer drug target: Inhibitors of this human enzyme might be able to treat most cancers without significant side effects. Telomerase is an enzyme that ...

Researchers at the Salk Institute have discovered an on/off switch for telomerase, an enzyme that rebuilds a cellular timekeeper known as a telomere. The scientists believe that the discovery could ...

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

Our DNA is organized into chromosomes, and the ends of chromosomes are protected with caps called telomeres; when cells divide, they lose a very small amount of DNA from those ends. Short telomeres ...

Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is ...

Neuroblastoma is a pediatric solid tumor of the sympathetic nervous system. 1 Clinical courses of patients with neuroblastoma vary greatly, ranging from spontaneous regression to fatal progression.

Science has identified in the plant kingdom the “missing link” of cellular immortality between human and single-celled animals, according to a new study led by scientists from Arizona State University ...

Researchers at the University of California, Berkeley have published the first detailed image of the molecular structure of human telomerase, the enzyme that lengthens chromosomes and extends the ...

Detection of Circulating Mammary Carcinoma Cells in the Peripheral Blood of Breast Cancer Patients Via a Nested Reverse Transcriptase Polymerase Chain Reaction Assay for Mammaglobin mRNA PURPOSE: ...