Endosomal stress, the aberrant accumulation of K63 ubiquitin chains on dysfunctional endosomes, activates the TAB2/3–TAK1–NF-kB and p62–Keap1–Nrf2 pathways, resulting in the expression of immune and ...
When proteins within the body get tagged with a molecule called ubiquitin, they are essentially marked for destruction. But they can be saved; a deubiquitinase enzyme can remove the ubiquitin, keeping ...
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