"Our intellectual property developed from extensive basic science studies in the mid to late 1990s where we identified a four amino acid sequence in the inactive (latent) form of a fibrotic and immune ...

Hong: TGF-beta signaling, particularly through the phosphorylated SMAD2/3 pathway, plays a critical role in the pathogenesis of PAH.

Why context is key for TGF-Beta's role in cancer metastasis The study brings together two longstanding areas of research for the Massagué Lab: TGF-beta signaling and metastasis.

The mice upregulated extracellular matrix (ECM) proteins and the ECM upstream regulator TGF-β1 (image above). Spinal cord, but not cortical, neurons contained 50 percent more of the type VI collagen ...

Why context is key for TGF-beta's role in cancer metastasis The study brings together two longstanding areas of research for the Massagué Lab: TGF-beta signaling and metastasis.

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

Decreased activity within the Transforming Growth Factor Beta (TGF-beta) pathway is associated with increased breast cancer risk, according to a study published by researchers at Northwestern ...

Mishra: The TGF-beta pathway has been found to be mutated in up to 40% of liver and GI cancers. This high prevalence indicates that it is a powerful and vital pathway to examine.