Only 25% of bacterial membrane transporters have functional annotation owing to the difficulty of experimental study and of accurate prediction of their function. Here we report a sequence-independent ...

Thiamine, vitamin B 1, was isolated in 1926 and synthesized in 1936. Its importance for preventing illness was known as early as the turn of the century. Thiamine requirements are related to energy ...

In bacteria, many genes involved in the biosynthesis of cofactors such as thiamine pyrophosphate (TPP) are regulated by riboswitches, regions in the 5' end of mRNAs to which the cofactor binds, ...

Toronto, ON - About a third of patients hospitalized for heart failure were found in a prospective, observational analysis to have thiamine deficiency, a condition that can be associated with symptoms ...