The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...

This confocal microscope image shows midbrain neurons (red) co-expressing the mu-opioid receptor (Oprm1, white) and cannabinoid receptor 1 (Cnr1, green). The interaction of these two reward pathways ...

Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.

Distinct brain circuits drive two key components of addiction to the synthetic opioid drug fentanyl, according to a new finding published in Nature (2024, DOI: 10.1038/s41586-024-07440-x). The ...

Sublocade (buprenorphine) is a brand-name subcutaneous injection prescribed for opioid use disorder. It works to help reduce the need for opioids by acting in certain areas of the brain called mu and ...

Listening to a favorite song can trigger a profound emotional response that rivals the feelings produced by biological ...

When the season turns darker and colder, animals’ brown fat starts to grow. The tissue produces heat efficiently and rapidly, and regulates appetite. Brown fat is also present in people. In a new ...