Adding two new teams would allow MLB to even the two leagues out at 16 teams apiece, making daily interleague play no longer necessary. It also creates the opportunity for realignment. Manfred hinted at the possibility of wholesale realignment based on geography during an appearance in ESPN's Sunday Night Baseball booth this past weekend.

During Sunday night's Little League Classic between the New York Mets and Seattle Mariners, Major League Baseball commissioner Rob Manfred talked about the possibility of not just expansion, but also a total overhaul of the leagues as we know them.

When MLB expansion comes up, which cities will get new teams is always the first topic. But there's another factor that will impact the entire sport: How will MLB realign its divisions -- and structure its playoffs -- to accommodate those new franchises.

While speaking on "The Pat McAfee Show," MLB insider Jeff Passan named two cities as likely future destinations for MLB expansion teams.