The coroner isn't ready to say why the death toll is down, but it coincides with retrenching on decriminalization ...

The largest review ever conducted on opioids for acute pain found that these widely prescribed drugs often deliver only small, short-lived benefits. For many common conditions, including some ...

A class of synthetic drugs called orphines is throwing a new wrench into the ever-evolving opioid crisis in the United States. These drugs have tenfold the potency of fentanyl and have led to numerous ...

The drugs are 10 times more dangerous than fentanyl. They are showing up in street drugs in the South and the Midwest, and will most likely spread to other regions. By Jan Hoffman Since last fall, new ...

Purdue Pharma, the bankrupted drug manufacturer at the center of the nation’s yearslong opioid epidemic, shut down May 1. The closure is part of a $7.4 billion deal reached after Purdue and the ...

Grace Point Treatment Center has published a new educational resource addressing whether opioid withdrawal can be fatal and what people and patients should understand about the risks and clinical ...

The number of U.S. individuals on long-term opioid therapy fell from 5.6 million in 2015 to 4.2 million in 2023. Co-prescribing opioids with gabapentinoids increased, however, reaching 58.7% in 2023.

Modified nitazenes, opioids 1,000 times stronger than morphine, show remarkably few adverse effects in rodents, renewing the potential of these drugs for pain relief. In an ambitious study that brings ...

Multiple states have raised the alarm in the past month about cychlorphine, a synthetic opioid tied to several dozen recent overdoses that is far stronger than fentanyl. Cychlorphine is part of a new ...

Articles in this report were published with editorial independence. The collection was made possible by the support of WVU Rockefeller Neuroscience Institute. On June 11, 2018, seeking relief from ...

Glycine is a major inhibitory neurotransmitter that reduces nerve activity, helping to regulate pain signals, motor control and sensory processing. Glycine transporter 2 (GlyT2) is a key regulator of ...