The FDA has begun soliciting feedback to inform the next version of the Prescription Drug User Fee Act. User fees remain ...

An 83-year-old man presented with fatigue, weight loss, and postural hypotension. Computed tomography of the abdomen revealed marked enlargement of both adrenal glands, and a diagnosis of primary a ...

Current international clinical practice guidelines recommend complete revascularization for patients with ST-segment elevation myocardial infarction (STEMI) with multivessel coronary artery disease ...

A man from rural India presented with redness and blurry vision in one eye. Examination was notable for panuveitis and a live worm in the posterior segment; the worm was removed in a pars plana vit ...

A 28-year-old woman was admitted to the hospital because of severe hypoxemia and right heart failure that had been caused by rapidly progressive pulmonary hypertension. A diagnosis was made.

A 72-year-old woman with a 30-year history of paraplegia was referred to the urology clinic for treatment of a bladder stone. CT of the abdomen revealed a large bladder stone with a tree ring ...

The rising tide of chronic kidney disease among patients with type 2 diabetes continues to challenge clinicians and health systems worldwide.1 Advances have been made in the management of chronic k ...

An 80-year-old woman presented with a 3-day history of abdominal pain. Imaging revealed numerous small gallstones in the gallbladder and cystic duct, consistent with cholecystitis.

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.

A 55-year-old man in the ICU had a sudden-onset vesicular rash appear across his trunk and arms. On examination, he was febrile and had clear vesicles resembling water droplets across his torso (sh ...

After a year of clinical rotations in which a medical student learns to face death up close, her experience on a silent meditation retreat provides her with new perspective on death and life.

Thinking of “culture” as a process in which tensions between social values are resolved, rather than as a fixed state, may help U.S. health care leaders envision an approach to transforming ...