Antipsychotic drugs have produced clinical benefit in psychosis, but D2- receptor–binding agents often have limited efficacy in treating blunted affect and cognitive impairment. Atypical antipsychotics were shown to have fewer side effects related to movement disorders, but they did not improve efficacy and were associated with adverse metabolic effects. New research findings are summarized in a short video. https://nej.md/2K6ukqi | The New England Journal of Medicine