In 2019, there were over 2.5 million estimated cases of meningitis worldwide. The highest incidence and mortality rates occur in Africa's meningitis belt. Mass vaccination campaigns have nearly eliminated meningitis caused by serogroup A in this region, however, high rates of disease from other serogroups still persist. A new trial assessed the safety and immunogenicity of NmCV-5, a pentavalent vaccine that covers serogroups A, C, W, and Y, as well as serogroup X, for which no licensed vaccines
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